Photo of radiation beams going through a water tank on a Radixact

Optical Cherenkov Imaging and Dosimetry (Grant R01EB023909)

During radiotherapy, Cherenkov emission is given off of the patient’s body. This emission can be picked up by a commercially-available Cherenkov camera, allowing real-time visualization of the amount and location of radiation going into the body. Our lab is searching for ways to improve the visual quality, spectral characteristics, and dosimetric capabilities of Cherenkov Cameras.

Currently, Cherenkov cameras are mounted on the ceiling within a linac vault. One or multiple cameras can be used.

This allows for real-time visualization of where radiation is being administered.

MOXI works with UW Veterinary Care to conduct Cherenkov imaging studies on their Radixact Tomotherapy system (technology developed here at UW!). A Tomotherapy system is a marriage of a linear accelerator and a CT scanner, providing real-time motion tracking of tumors and synchronizing treatment delivery. These systems present new Cherenkov imaging and visualization challenges that our lab seeks to resolve.

Other cameras can be used to characterize the emission spectra of Cherenkov radiation. Cherenkov emission appears blue in water, but red in tissue. This spectrum changes as it penetrates tissue, since Cherenkov radiation is both created and emitted at different depths. This research hopes to enhance our understanding of radiation therapy and its effect on the body.

Cherenkov intensity shows a very linear correlation with radiation dose, making it a promising technology in radiation in dosimetry. Using scintillating dots, as shown on the left, allows us to quantify radiation dose in total body irradiation (TBI) conditions.